Biom 972: Variance Components
Mixed models arise in many experimental situations. While a lot of attention is focused on fixed effects, variance components are also of interest. When examining fixed effects variance components play an important role in experimental design, testing, and estimation. In addition, variance components (and functions of them) are of interest in themselves. The amount of variability present in a population is important both in determining the opportunity to improve the population through selection and in quality control.
The purpose of this course is to develop an understanding of different methods of estimating variance components in linear mixed models. To accomplish this we will need to brush up on our matrix algebra and review mixed models. The necessary matrix algebra will be introduced as needed. Appendix M summarizes most of the results we will need for this course. An introduction to mixed models is contained in Chapter 1. Chapter 2 contains a brief history and is recommended reading.
We will be using a number of computer packages. PROC IML will be used for examining the underlying mechanics of the estimation procedures. PROC MIXED will be also used to estimate variance components. While standard statistical packages are often inadequate for the analysis of large data sets we will not be using any of the more specialized programs. It is also important to note that in many cases there may not be a program that is capable of conducting the analysis.
|Office:||104 D Miller Hall|
|Office Hours:||MWF 11:00-12:00 and by appointment|
|Text Book:||Variance Components, Searle, S.R., Casella G. and McCulloch, C.E. (1992)|
To view the Course Syllabus click on Course Syllabus . If Acrobat Reader is not installed on your computer click on .
|Homework:||Approximately once a
|Exams:||Two exams, will be announced at least one week in advance|
|Final Exam:||Wednesday, May 2 at
10:00||Check Grades:||Blackboard Course Info|