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Department of Statistics

Turning data into knowledge to solve real world problems

Steve Ladunga

Professor
Dr. Istvan (Steve) Ladunga
Department of Statistics
University of Nebraska - Lincoln
E145 BEAD
Lincoln NE 68588-0665

Office Phone: 402 472 6074
email:sladunga2@unl.edu
Web Page: http://compbio.unl.edu/steve_ladunga.html

Research Interest:

Computational Biology (Bioinformatics), Biostatistics, Epigenetics, Optimization, Machine Learning

Selected publications:

Belch, Y, Yang, J, Malkaram, SA , Liu, R , Riethoven, JJM , Ladunga, I (submitted). Limits to Wide-Spread Nucleosome Repositioning Preserve Chromatin Integrity.

Ladunga I. (Editor) Computational Biology of Transcription Factor Binding. In the series "Methods in Molecular Biology", Series Editor John Walker, Humana Press. Expected date of publication: Spring 2010.

Ladunga I. (2007) More complete silencing by fewer siRNAs: Transparent optimized design and a biophysical signature. Nucl Acids Res 35(2):433-440. 4.

Prokoupek A, Kachman SD, Ladunga I, Harshman LG. Transcriptional profiling of the sperm storage organs of Drosophila melanogaster. Insect Mol Biol, 18(4):465-475.

Abdelaty S, Alvarez-Venegas R, Yilmaz M, Le O, Hou Q, Sader M, Al-Abdallat A, Xia Y, Lu G, Ladunga I, Avramova Z. (2008) The highly similar Arabidopsis homologs of Trithorax atx1 and atx2 encode divergent biochemical functions. Plant Cell, 20:568-579.

Wang Y, Ladunga I, Miller AR, Horken KM, Plucinak T, Weeks DP, Bailey CP. (2008) The small ubiquitin-like modifier (SUMO) and SUMO-conjugating system of Chlamydomonas reinhardtii. Genetics, 179(1):177-192.

Ladunga I (2009) Finding similar nucleotide sequences using network BLAST searches. Curr Protoc Bioinformatics. Chapter 3:Unit 3.3.

Ladunga I (2009) Finding homologs in amino acid sequences using network BLAST searches. Curr Protoc Bioinformatics. Chapter 3:Unit 3.4.

Ladunga I (1999) PHYSEAN: PHYsical SEquence ANalysis of Proteins. Bioinformatics, 15: 128-138.

Ladunga I (2000) Large-scale discovery of secretory proteins from nucleic acid sequences. Current Opinion in Biotechnology,11:13-18.

Ladunga I and Smith RF(1997) Amino acid substitution patterns conserve folding of proteins by preserving steric and hydrophobicity properties. Protein Engineering 10: 187-196.

Ladunga I, Wiese BA and Smith RF (1996) FASTA-SWAP and FASTA-PAT: pattern database searches using combinations of aligned amino acids and a novel scoring theory. J. Mol. Biol. 259: 840-854.

Karlin S and Ladunga I (1994). Novel comparisons of genomic sequences in Eukaryotes. Proc. Natl. Acad. Sci. U.S.A., 91: 2832-12836.

Karlin S, Ladunga I and Blaisdell BE (1994). Heterogeneity of genomes: measures and values. Proc. Natl. Acad. Sci. U.S.A., 91: 12837-12841.

Patents and copyrights:

Ladunga I et al. (2000 - 2007) Over 100 patents on sequences of secreted proteins, filed by Celera Genomics Corp.

Ladunga I. Methods and Systems for the Identification of Protein Classes. Sole inventor, filed by SmithKline Beecham, Granted: Nov. 16, 1999, Patent Number: 5,987,390.

Muruganujan A; Guo N; Mi H; Rabkin S; Thomas PD; Diemer K; Kejariwal A; Ladunga I; et al.: A browsable database for biological use. 2004, Patent Number: WO2004053769.

Ladunga I, Smith RF and Wiese BA: FASTA-SWAP and FASTA-PAT: pattern database searches using combinations, 1996. Copyright.